Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver

Human cytochrome P450 oxidoreductase (POR) provides electrons for all microsomal cytochromes P450 (P450s) and plays an indispensable role in drug metabolism catalyzed by this family of enzymes. We evaluated 100 human liver samples and found that POR protein content varied 12.8-fold, from 12.59 to 16...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Zhang, Hai-Feng, Li, Zhi-Hui, Liu, Jia-Yu, Liu, Ting-Ting, Wang, Ping, Fang, Yan, Zhou, Jun, Cui, Ming-Zhu, Gao, Na, Tian, Xin, Gao, Jie, Wen, Qiang, Jia, Lin-Jing, Qiao, Hai-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986620/
https://ncbi.nlm.nih.gov/pubmed/27271371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.069849
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