Prediction of cytochrome P450-mediated drug clearance in humans based on the measured activities of selected CYPs

Determining drug-metabolizing enzyme activities on an individual basis is an important component of personalized medicine, and cytochrome P450 enzymes (CYPs) play a principal role in hepatic drug metabolism. Herein, a simple method for predicting the major CYP-mediated drug clearance in vitro and in...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Gao, Jie, Wang, Jie, Gao, Na, Tian, Xin, Zhou, Jun, Fang, Yan, Zhang, Hai-Feng, Wen, Qiang, Jia, Lin-Jing, Zou, Dan, Qiao, Hai-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696450/
https://ncbi.nlm.nih.gov/pubmed/29054967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20171161
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