Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFα

Acute liver injury (ALI) is characterized by hepatocyte damage and inflammation. In the present study, we examined whether the absence of Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, influences ALI induced by D-galactosamine (D-GalN...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yang, Xu, Fujisawa, Masayoshi, Yoshimura, Teizo, Ohara, Toshiaki, Sato, Miwa, Mino, Megumi, San, Thar Htet, Gao, Tong, Kunkel, Steven L., Matsukawa, Akihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760641/
https://ncbi.nlm.nih.gov/pubmed/29317674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18380-0
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