Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFα

Acute liver injury (ALI) is characterized by hepatocyte damage and inflammation. In the present study, we examined whether the absence of Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, influences ALI induced by D-galactosamine (D-GalN...

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Vydáno v:Sci Rep
Hlavní autoři: Yang, Xu, Fujisawa, Masayoshi, Yoshimura, Teizo, Ohara, Toshiaki, Sato, Miwa, Mino, Megumi, San, Thar Htet, Gao, Tong, Kunkel, Steven L., Matsukawa, Akihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760641/
https://ncbi.nlm.nih.gov/pubmed/29317674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18380-0
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