Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFα

Acute liver injury (ALI) is characterized by hepatocyte damage and inflammation. In the present study, we examined whether the absence of Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, influences ALI induced by D-galactosamine (D-GalN...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Yang, Xu, Fujisawa, Masayoshi, Yoshimura, Teizo, Ohara, Toshiaki, Sato, Miwa, Mino, Megumi, San, Thar Htet, Gao, Tong, Kunkel, Steven L., Matsukawa, Akihiro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760641/
https://ncbi.nlm.nih.gov/pubmed/29317674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18380-0
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