Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFα

Acute liver injury (ALI) is characterized by hepatocyte damage and inflammation. In the present study, we examined whether the absence of Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, influences ALI induced by D-galactosamine (D-GalN...

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Publicat a:Sci Rep
Autors principals: Yang, Xu, Fujisawa, Masayoshi, Yoshimura, Teizo, Ohara, Toshiaki, Sato, Miwa, Mino, Megumi, San, Thar Htet, Gao, Tong, Kunkel, Steven L., Matsukawa, Akihiro
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760641/
https://ncbi.nlm.nih.gov/pubmed/29317674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18380-0
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