Endogenous Reprogramming of Alpha Cells into Beta Cells Induced by Viral Gene Therapy Reverses Autoimmune Diabetes

Successful strategies for treating type 1 diabetes need to restore the function of pancreatic beta cells that are destroyed by the immune system and overcome further destruction of insulin-producing cells. Here, we infused adeno-associated virus carrying Pdx1 and MafA expression cassettes through th...

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Bibliografiska uppgifter
I publikationen:Cell Stem Cell
Huvudupphovsmän: Xiao, Xiangwei, Guo, Ping, Shiota, Chiyo, Zhang, Ting, Coudriet, Gina M, Fischbach, Shane, Prasadan, Krishna, Fusco, Joseph, Ramachandran, Sabarinathan, Witkowski, Piotr, Piganelli, Jon D, Gittes, George K
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757249/
https://ncbi.nlm.nih.gov/pubmed/29304344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.11.020
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