Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice

The mechanisms underlying the effects of exocrine dysfunction on the development of diabetes remain largely unknown. Here we show that pancreatic depletion of SMAD7 resulted in age-dependent increases in β cell dysfunction with accelerated glucose intolerance, followed by overt diabetes. The acceler...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Xiao, Xiangwei, Chen, Congde, Guo, Ping, Zhang, Ting, Fischbach, Shane, Fusco, Joseph, Shiota, Chiyo, Prasadan, Krishna, Dong, Henry, Gittes, George K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336177/
https://ncbi.nlm.nih.gov/pubmed/28057752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770032
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