Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice

The mechanisms underlying the effects of exocrine dysfunction on the development of diabetes remain largely unknown. Here we show that pancreatic depletion of SMAD7 resulted in age-dependent increases in β cell dysfunction with accelerated glucose intolerance, followed by overt diabetes. The acceler...

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Publicado en:J Biol Chem
Autores principales: Xiao, Xiangwei, Chen, Congde, Guo, Ping, Zhang, Ting, Fischbach, Shane, Fusco, Joseph, Shiota, Chiyo, Prasadan, Krishna, Dong, Henry, Gittes, George K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336177/
https://ncbi.nlm.nih.gov/pubmed/28057752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770032
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