SMAD3/Stat3 Signaling Mediates β-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis–Related Diabetes

Many patients with chronic pancreatitis develop diabetes (chronic pancreatitis–related diabetes [CPRD]) through an undetermined mechanism. Here we used long-term partial pancreatic duct ligation (PDL) as a model to study CPRD. We found that long-term PDL induced significant β-cell dedifferentiation,...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Xiao, Xiangwei, Fischbach, Shane, Zhang, Tina, Chen, Congde, Sheng, Qingfeng, Zimmerman, Ray, Patnaik, Sneha, Fusco, Joseph, Ming, Yungching, Guo, Ping, Shiota, Chiyo, Prasadan, Krishna, Gangopadhyay, Nupur, Husain, Sohail Z., Dong, Henry, Gittes, George K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2017
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606322/
https://ncbi.nlm.nih.gov/pubmed/28775125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0537
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