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M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7
Determination of signaling pathways that regulate beta-cell replication is critical for beta-cell therapy. Here, we show that blocking pancreatic macrophage infiltration after pancreatic duct ligation (PDL) completely inhibits beta-cell proliferation. The TGFβ superfamily signaling inhibitor SMAD7 w...
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| Hlavní autoři: | , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3977272/ https://ncbi.nlm.nih.gov/pubmed/24639504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321347111 |
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