M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

Determination of signaling pathways that regulate beta-cell replication is critical for beta-cell therapy. Here, we show that blocking pancreatic macrophage infiltration after pancreatic duct ligation (PDL) completely inhibits beta-cell proliferation. The TGFβ superfamily signaling inhibitor SMAD7 w...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Xiao, Xiangwei, Gaffar, Iljana, Guo, Ping, Wiersch, John, Fischbach, Shane, Peirish, Lauren, Song, Zewen, El-Gohary, Yousef, Prasadan, Krishna, Shiota, Chiyo, Gittes, George K.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977272/
https://ncbi.nlm.nih.gov/pubmed/24639504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321347111
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky