M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

Determination of signaling pathways that regulate beta-cell replication is critical for beta-cell therapy. Here, we show that blocking pancreatic macrophage infiltration after pancreatic duct ligation (PDL) completely inhibits beta-cell proliferation. The TGFβ superfamily signaling inhibitor SMAD7 w...

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Bibliografiske detaljer
Main Authors: Xiao, Xiangwei, Gaffar, Iljana, Guo, Ping, Wiersch, John, Fischbach, Shane, Peirish, Lauren, Song, Zewen, El-Gohary, Yousef, Prasadan, Krishna, Shiota, Chiyo, Gittes, George K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977272/
https://ncbi.nlm.nih.gov/pubmed/24639504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321347111
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