Neurogenin3 Activation Is Not Sufficient to Direct Duct-to-Beta Cell Transdifferentiation in the Adult Pancreas

It remains controversial whether adult pancreatic ducts harbor facultative beta cell progenitors. Because neurogenin3 (Ngn3) is a key determinant of pancreatic endocrine cell neogenesis during embryogenesis, many studies have also relied upon Ngn3 expression as evidence of beta cell neogenesis in ad...

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Autors principals: Xiao, Xiangwei, Guo, Ping, Shiota, Chiyo, Prasadan, Krishna, El-Gohary, Yousef, Wiersch, John, Gaffar, Iljana, Gittes, George K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757194/
https://ncbi.nlm.nih.gov/pubmed/23867457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484022
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