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Incorporation of second coordination sphere d-amino acids alters Cd(II) geometries in designed thiolate-rich proteins

We use a de Novo protein design strategy to demonstrate that the second coordination sphere of a metal site plays a key role in controlling coordination geometries of Cd(II)-tris-thiolate complexes. Specifically, we show that alteration of chirality within the core hydrophobic packing region of a th...

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Xehetasun bibliografikoak
Argitaratua izan da:J Biol Inorg Chem
Egile Nagusiak: Ruckthong, Leela, Deb, Aniruddha, Hemmingsen, Lars, Penner-Hahn, James E., Pecoraro, Vincent L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756694/
https://ncbi.nlm.nih.gov/pubmed/29218636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-017-1515-7
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