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Design of Thiolate Rich Metal Binding Sites within a Peptidic Framework
A de novo protein design strategy provides a powerful tool to elucidate how heavy metals interact with proteins. Cysteine derivatives of the TRI peptide family (Ac-G(LKALEEK)(4)G-NH(2)) have been shown to bind heavy metals in an unusual trigonal geometry. Our present objective was to design binding...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650386/ https://ncbi.nlm.nih.gov/pubmed/18959366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic8009817 |
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