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Design of Thiolate Rich Metal Binding Sites within a Peptidic Framework

A de novo protein design strategy provides a powerful tool to elucidate how heavy metals interact with proteins. Cysteine derivatives of the TRI peptide family (Ac-G(LKALEEK)(4)G-NH(2)) have been shown to bind heavy metals in an unusual trigonal geometry. Our present objective was to design binding...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Łuczkowski, Marek, Stachura, Monika, Schirf, Virgil, Demeler, Borries, Hemmingsen, Lars, Pecoraro, Vincent L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650386/
https://ncbi.nlm.nih.gov/pubmed/18959366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic8009817
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