Llwytho...

Incorporation of second coordination sphere d-amino acids alters Cd(II) geometries in designed thiolate-rich proteins

We use a de Novo protein design strategy to demonstrate that the second coordination sphere of a metal site plays a key role in controlling coordination geometries of Cd(II)-tris-thiolate complexes. Specifically, we show that alteration of chirality within the core hydrophobic packing region of a th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Inorg Chem
Prif Awduron: Ruckthong, Leela, Deb, Aniruddha, Hemmingsen, Lars, Penner-Hahn, James E., Pecoraro, Vincent L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756694/
https://ncbi.nlm.nih.gov/pubmed/29218636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-017-1515-7
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!