Deficiency in protein tyrosine phosphatase PTP1B shortens lifespan and leads to development of acute leukemia

Protein tyrosine phosphatase PTP1B is a critical regulator of signaling pathways controlling metabolic homeostasis, cell proliferation and immunity. In this study, we report that global or myeloid-specific deficiency of PTP1B in mice decreases lifespan. We demonstrate that myeloid-specific deficienc...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Le Sommer, Samantha, Morrice, Nicola, Pesaresi, Martina, Thompson, Dawn, Vickers, Mark A., Murray, Graeme I., Mody, Nimesh, Neel, Benjamin G, Bence, Kendra K, Wilson, Heather M, Delibegovic, Mirela
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756472/
https://ncbi.nlm.nih.gov/pubmed/29122767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0946
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