Deficiency in protein tyrosine phosphatase PTP1B shortens lifespan and leads to development of acute leukemia

Protein tyrosine phosphatase PTP1B is a critical regulator of signaling pathways controlling metabolic homeostasis, cell proliferation and immunity. In this study, we report that global or myeloid-specific deficiency of PTP1B in mice decreases lifespan. We demonstrate that myeloid-specific deficienc...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Cancer Res
Main Authors: Le Sommer, Samantha, Morrice, Nicola, Pesaresi, Martina, Thompson, Dawn, Vickers, Mark A., Murray, Graeme I., Mody, Nimesh, Neel, Benjamin G, Bence, Kendra K, Wilson, Heather M, Delibegovic, Mirela
Formato: Artigo
Idioma:Inglês
Publicado: 2017
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756472/
https://ncbi.nlm.nih.gov/pubmed/29122767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0946
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares