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Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress
OBJECTIVE—The protein tyrosine phosphatase PTP1B is a negative regulator of insulin signaling; consequently, mice deficient in PTP1B are hypersensitive to insulin. Because PTP1B(−/−) mice have diminished fat stores, the extent to which PTP1B directly regulates glucose homeostasis is unclear. Previou...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Diabetes Association
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646057/ https://ncbi.nlm.nih.gov/pubmed/19074988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0913 |
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