Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

OBJECTIVE—The protein tyrosine phosphatase PTP1B is a negative regulator of insulin signaling; consequently, mice deficient in PTP1B are hypersensitive to insulin. Because PTP1B(−/−) mice have diminished fat stores, the extent to which PTP1B directly regulates glucose homeostasis is unclear. Previou...

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Detalhes bibliográficos
Main Authors: Delibegovic, Mirela, Zimmer, Derek, Kauffman, Caitlin, Rak, Kimberly, Hong, Eun-Gyoung, Cho, You-Ree, Kim, Jason K., Kahn, Barbara B., Neel, Benjamin G., Bence, Kendra K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646057/
https://ncbi.nlm.nih.gov/pubmed/19074988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0913
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