Protein Tyrosine Phosphatase PTP1B Is Involved in Hippocampal Synapse Formation and Learning

ER-bound PTP1B is expressed in hippocampal neurons, and accumulates among neurite contacts. PTP1B dephosphorylates ß-catenin in N-cadherin complexes ensuring cell-cell adhesion. Here we show that endogenous PTP1B, as well as expressed GFP-PTP1B, are present in dendritic spines of hippocampal neurons...

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Détails bibliographiques
Auteurs principaux: Fuentes, Federico, Zimmer, Derek, Atienza, Marybless, Schottenfeld, Jamie, Penkala, Ian, Bale, Tracy, Bence, Kendra K., Arregui, Carlos O.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402386/
https://ncbi.nlm.nih.gov/pubmed/22844492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041536
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