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Protein Tyrosine Phosphatase PTP1B Is Involved in Hippocampal Synapse Formation and Learning
ER-bound PTP1B is expressed in hippocampal neurons, and accumulates among neurite contacts. PTP1B dephosphorylates ß-catenin in N-cadherin complexes ensuring cell-cell adhesion. Here we show that endogenous PTP1B, as well as expressed GFP-PTP1B, are present in dendritic spines of hippocampal neurons...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3402386/ https://ncbi.nlm.nih.gov/pubmed/22844492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041536 |
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