Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor()

Protein tyrosine phosphatase 1B (PTP1B) is a known regulator of central metabolic signaling, and mice with whole brain-, leptin receptor (LepRb) expressing cell-, or proopiomelanocortin neuron-specific PTP1B-deficiency are lean, leptin hypersensitive, and display improved glucose homeostasis. Howeve...

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Main Authors: Tsou, Ryan C., Rak, Kimberly S., Zimmer, Derek J., Bence, Kendra K.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986631/
https://ncbi.nlm.nih.gov/pubmed/24749060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.01.008
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