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Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor()
Protein tyrosine phosphatase 1B (PTP1B) is a known regulator of central metabolic signaling, and mice with whole brain-, leptin receptor (LepRb) expressing cell-, or proopiomelanocortin neuron-specific PTP1B-deficiency are lean, leptin hypersensitive, and display improved glucose homeostasis. Howeve...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3986631/ https://ncbi.nlm.nih.gov/pubmed/24749060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.01.008 |
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