Deficiency of PTP1B in Leptin Receptor-Expressing Neurons Leads to Decreased Body Weight and Adiposity in Mice

Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed tyrosine phosphatase implicated in the negative regulation of leptin and insulin receptor signaling. PTP1B(−/−) mice possess a lean metabolic phenotype attributed at least partially to improved hypothalamic leptin sensitivity. Inter...

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Bibliographic Details
Main Authors: Tsou, Ryan C., Zimmer, Derek J., De Jonghe, Bart C., Bence, Kendra K.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2012
Subjects:
Energy Balance-Obesity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423620/
https://ncbi.nlm.nih.gov/pubmed/22802463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1548
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