Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure

The adipose tissue-derived hormone leptin regulates energy balance through catabolic effects on central circuits, including proopiomelanocortin (POMC) neurons. Leptin activation of POMC neurons increases thermogenesis and locomotor activity. Protein tyrosine phosphatase 1B (PTP1B) is an important ne...

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Bibliographic Details
Main Authors: De Jonghe, Bart C., Hayes, Matthew R., Banno, Ryoichi, Skibicka, Karolina P., Zimmer, Derek J., Bowen, Kerisha A., Leichner, Theresa M., Alhadeff, Amber L., Kanoski, Scott E., Cyr, Nicole E., Nillni, Eduardo A., Grill, Harvey J., Bence, Kendra K.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118594/
https://ncbi.nlm.nih.gov/pubmed/21406615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00639.2010
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