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Deficiency of PTP1B in Leptin Receptor-Expressing Neurons Leads to Decreased Body Weight and Adiposity in Mice
Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed tyrosine phosphatase implicated in the negative regulation of leptin and insulin receptor signaling. PTP1B(−/−) mice possess a lean metabolic phenotype attributed at least partially to improved hypothalamic leptin sensitivity. Inter...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Endocrine Society
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3423620/ https://ncbi.nlm.nih.gov/pubmed/22802463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1548 |
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