Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR(−/−) mouse model of atherosclerosis

Cardiovascular disease (CVD) is the most prevalent cause of mortality among patients with type 1 or type 2 diabetes, due to accelerated atherosclerosis. Recent evidence suggests a strong link between atherosclerosis and insulin resistance, due to impaired insulin receptor (IR) signalling. Here, we d...

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Detalhes bibliográficos
Publicado no:Clin Sci (Lond)
Main Authors: Thompson, Dawn, Morrice, Nicola, Grant, Louise, Le Sommer,  Samantha, Lees, Emma K., Mody, Nimesh, Wilson, Heather M., Delibegovic, Mirela
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365594/
https://ncbi.nlm.nih.gov/pubmed/28899902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20171066
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