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eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast
The translation pre-initiation complex (PIC) scans the mRNA for an AUG codon in favorable context, and AUG recognition stabilizes a closed PIC conformation. The unstructured N-terminal tail (NTT) of yeast eIF1A deploys five basic residues to contact tRNA(i), mRNA, or 18S rRNA exclusively in the clos...
Guardat en:
| Publicat a: | eLife |
|---|---|
| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5756025/ https://ncbi.nlm.nih.gov/pubmed/29206102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31250 |
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