eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast

The translation pre-initiation complex (PIC) scans the mRNA for an AUG codon in favorable context, and AUG recognition stabilizes a closed PIC conformation. The unstructured N-terminal tail (NTT) of yeast eIF1A deploys five basic residues to contact tRNA(i), mRNA, or 18S rRNA exclusively in the clos...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Martin-Marcos, Pilar, Zhou, Fujun, Karunasiri, Charm, Zhang, Fan, Dong, Jinsheng, Nanda, Jagpreet, Kulkarni, Shardul D, Sen, Neelam Dabas, Tamame, Mercedes, Zeschnigk, Michael, Lorsch, Jon R, Hinnebusch, Alan G
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Assuntos:
Biochemistry and Chemical Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756025/
https://ncbi.nlm.nih.gov/pubmed/29206102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31250
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