Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs

Interpretation of positive genotoxicity findings using the current in vitro testing battery is a major challenge to industry and regulatory agencies. These tests, especially mammalian cell assays, have high sensitivity but suffer from low specificity, leading to high rates of irrelevant positive fin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Li, Heng-Hong, Chen, Renxiang, Hyduke, Daniel R., Williams, Andrew, Frötschl, Roland, Ellinger-Ziegelbauer, Heidrun, O’Lone, Raegan, Yauk, Carole L., Aubrecht, Jiri, Fornace, Albert J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754797/
https://ncbi.nlm.nih.gov/pubmed/29203651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714109114
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