Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs

Interpretation of positive genotoxicity findings using the current in vitro testing battery is a major challenge to industry and regulatory agencies. These tests, especially mammalian cell assays, have high sensitivity but suffer from low specificity, leading to high rates of irrelevant positive fin...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Li, Heng-Hong, Chen, Renxiang, Hyduke, Daniel R., Williams, Andrew, Frötschl, Roland, Ellinger-Ziegelbauer, Heidrun, O’Lone, Raegan, Yauk, Carole L., Aubrecht, Jiri, Fornace, Albert J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754797/
https://ncbi.nlm.nih.gov/pubmed/29203651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714109114
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