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Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs
Interpretation of positive genotoxicity findings using the current in vitro testing battery is a major challenge to industry and regulatory agencies. These tests, especially mammalian cell assays, have high sensitivity but suffer from low specificity, leading to high rates of irrelevant positive fin...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5754797/ https://ncbi.nlm.nih.gov/pubmed/29203651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714109114 |
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