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Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells

The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion article, a genomic biomarker was developed in human TK6 cells to classify chemicals as gen...

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Detalhes bibliográficos
Publicado no:Environ Mol Mutagen
Main Authors: Buick, Julie K., Moffat, Ivy, Williams, Andrew, Swartz, Carol D., Recio, Leslie, Hyduke, Daniel R., Li, Heng‐Hong, Fornace, Albert J., Aubrecht, Jiri, Yauk, Carole L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506226/
https://ncbi.nlm.nih.gov/pubmed/25733247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.21940
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