Small molecule inhibition of Axl targets tumor immune suppression and enhances chemotherapy in pancreatic cancer

Activation of the receptor tyrosine kinase Axl is associated with poor outcomes in pancreatic cancer (PDA), where it coordinately mediates immune evasion and drug resistance. Here we demonstrate that the selective Axl kinase inhibitor BGB324 targets the tumor-immune interface to blunt the aggressive...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Ludwig, Kathleen F., Du, Wenting, Sorrelle, Noah B., Wnuk-Lipinska, Katarzyna, Topalovski, Mary, Toombs, Jason E., Cruz, Victoria H., Yabuuchi, Shinichi, Rajeshkumar, N.V., Maitra, Anirban, Lorens, James B., Brekken, Rolf A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754222/
https://ncbi.nlm.nih.gov/pubmed/29180468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1973
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