Warfarin blocks Gas6-mediated Axl activation required for pancreatic cancer epithelial plasticity and metastasis

Repurposing ‘old’ drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K “antagonist” used clinically for the prevention of thrombosis for over 50 years, has been shown to have anti-cancer effects. We hypothesized that the molecular mechanis...

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Pubblicato in:Cancer Res
Autori principali: Kirane, Amanda, Ludwig, Kathleen F., Sorrelle, Noah, Haaland, Gry, Sandal, Tone, Ranaweera, Renate, Toombs, Jason E., Wang, Miao, Dineen, Sean P., Micklem, David, Dellinger, Michael T., Lorens, James B., Brekken, Rolf A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572915/
https://ncbi.nlm.nih.gov/pubmed/26206560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2887-T
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