Small molecule inhibition of Axl targets tumor immune suppression and enhances chemotherapy in pancreatic cancer

Activation of the receptor tyrosine kinase Axl is associated with poor outcomes in pancreatic cancer (PDA), where it coordinately mediates immune evasion and drug resistance. Here we demonstrate that the selective Axl kinase inhibitor BGB324 targets the tumor-immune interface to blunt the aggressive...

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Vydáno v:Cancer Res
Hlavní autoři: Ludwig, Kathleen F., Du, Wenting, Sorrelle, Noah B., Wnuk-Lipinska, Katarzyna, Topalovski, Mary, Toombs, Jason E., Cruz, Victoria H., Yabuuchi, Shinichi, Rajeshkumar, N.V., Maitra, Anirban, Lorens, James B., Brekken, Rolf A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754222/
https://ncbi.nlm.nih.gov/pubmed/29180468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1973
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