Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing, fatal disorder with no effective treatment. We used simple genetic models of ALS to screen phenotypically for potential therapeutic compounds. We screened libraries of compounds in C. elegans, validated hits in zebrafish, and tested the m...

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Publicat a:JCI Insight
Autors principals: Patten, Shunmoogum A., Aggad, Dina, Martinez, Jose, Tremblay, Elsa, Petrillo, Janet, Armstrong, Gary A.B., La Fontaine, Alexandre, Maios, Claudia, Liao, Meijiang, Ciura, Sorana, Wen, Xiao-Yan, Rafuse, Victor, Ichida, Justin, Zinman, Lorne, Julien, Jean-Pierre, Kabashi, Edor, Robitaille, Richard, Korngut, Lawrence, Parker, J. Alexander, Drapeau, Pierre
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752378/
https://ncbi.nlm.nih.gov/pubmed/29202456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97152
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