Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing, fatal disorder with no effective treatment. We used simple genetic models of ALS to screen phenotypically for potential therapeutic compounds. We screened libraries of compounds in C. elegans, validated hits in zebrafish, and tested the m...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Patten, Shunmoogum A., Aggad, Dina, Martinez, Jose, Tremblay, Elsa, Petrillo, Janet, Armstrong, Gary A.B., La Fontaine, Alexandre, Maios, Claudia, Liao, Meijiang, Ciura, Sorana, Wen, Xiao-Yan, Rafuse, Victor, Ichida, Justin, Zinman, Lorne, Julien, Jean-Pierre, Kabashi, Edor, Robitaille, Richard, Korngut, Lawrence, Parker, J. Alexander, Drapeau, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752378/
https://ncbi.nlm.nih.gov/pubmed/29202456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97152
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados