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Monoacylglycerol lipase inhibitor JZL184 prevents HIV-1 gp120-induced synapse loss by altering endocannabinoid signaling

Monoacylglycerol lipase (MGL) hydrolyzes 2-arachidonoylglycerol to arachidonic acid and glycerol. Inhibition of MGL may attenuate neuroinflammation by enhancing endocannabinoid signaling and decreasing prostaglandin (PG) production. Almost half of HIV infected individuals are afflicted with HIV-asso...

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Zhang, Xinwen, Thayer, Stanley A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752128/
https://ncbi.nlm.nih.gov/pubmed/29061509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.10.023
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