Interleukin-1 blockade in acute decompensated heart failure: A randomized, double-blinded, placebo-controlled pilot study

BACKGROUND: Heart failure is an inflammatory disease. Patients with acute decompensated heart failure (ADHF) exhibit significant inflammatory activity upon admission. We hypothesized that Interleukin-1 (IL-1) blockade, with anakinra (Kineret™, Swedish Orphan Biovitrum), would quench the acute inflam...

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Publicat a:J Cardiovasc Pharmacol
Autors principals: Van Tassell, Benjamin W., Abouzaki, Nayef A., Erdle, Claudia Oddi, Carbone, Salvatore, Trankle, Cory, Melchior, Ryan D., Turlington, Jeremy S., Thurber, Clint, Christopher, Sanah, Dixon, Dave L., Fronk, Daniel Taylor, Thomas, Christopher S., Rose, Scott W., Buckley, Leo Francis, Dinarello, Charles A., Biondi-Zoccai, Giuseppe, Abbate, Antonio
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749643/
https://ncbi.nlm.nih.gov/pubmed/26906034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000378
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