Interleukin-1 blockade in acute decompensated heart failure: A randomized, double-blinded, placebo-controlled pilot study

BACKGROUND: Heart failure is an inflammatory disease. Patients with acute decompensated heart failure (ADHF) exhibit significant inflammatory activity upon admission. We hypothesized that Interleukin-1 (IL-1) blockade, with anakinra (Kineret™, Swedish Orphan Biovitrum), would quench the acute inflam...

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Detalhes bibliográficos
Publicado no:J Cardiovasc Pharmacol
Main Authors: Van Tassell, Benjamin W., Abouzaki, Nayef A., Erdle, Claudia Oddi, Carbone, Salvatore, Trankle, Cory, Melchior, Ryan D., Turlington, Jeremy S., Thurber, Clint, Christopher, Sanah, Dixon, Dave L., Fronk, Daniel Taylor, Thomas, Christopher S., Rose, Scott W., Buckley, Leo Francis, Dinarello, Charles A., Biondi-Zoccai, Giuseppe, Abbate, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749643/
https://ncbi.nlm.nih.gov/pubmed/26906034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000378
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