Interleukin-1 blockade in acute decompensated heart failure: A randomized, double-blinded, placebo-controlled pilot study

BACKGROUND: Heart failure is an inflammatory disease. Patients with acute decompensated heart failure (ADHF) exhibit significant inflammatory activity upon admission. We hypothesized that Interleukin-1 (IL-1) blockade, with anakinra (Kineret™, Swedish Orphan Biovitrum), would quench the acute inflam...

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Vydáno v:J Cardiovasc Pharmacol
Hlavní autoři: Van Tassell, Benjamin W., Abouzaki, Nayef A., Erdle, Claudia Oddi, Carbone, Salvatore, Trankle, Cory, Melchior, Ryan D., Turlington, Jeremy S., Thurber, Clint, Christopher, Sanah, Dixon, Dave L., Fronk, Daniel Taylor, Thomas, Christopher S., Rose, Scott W., Buckley, Leo Francis, Dinarello, Charles A., Biondi-Zoccai, Giuseppe, Abbate, Antonio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749643/
https://ncbi.nlm.nih.gov/pubmed/26906034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000378
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