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Leukemia-specific delivery of mutant NOTCH1 targeted therapy
On-target drug delivery remains a challenge in cancer precision medicine; it is difficult to deliver a targeted therapy to cancer cells without incurring toxicity to normal tissues. The SERCA (sarco-endoplasmic reticulum Ca(2+) ATPase) inhibitor thapsigargin inhibits mutant NOTCH1 receptors compared...
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| 發表在: | J Exp Med |
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| Main Authors: | , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Rockefeller University Press
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5748843/ https://ncbi.nlm.nih.gov/pubmed/29158376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151778 |
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