Leukemia-specific delivery of mutant NOTCH1 targeted therapy

On-target drug delivery remains a challenge in cancer precision medicine; it is difficult to deliver a targeted therapy to cancer cells without incurring toxicity to normal tissues. The SERCA (sarco-endoplasmic reticulum Ca(2+) ATPase) inhibitor thapsigargin inhibits mutant NOTCH1 receptors compared...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Exp Med
Egile Nagusiak: Roti, Giovanni, Qi, Jun, Kitara, Samuel, Sanchez-Martin, Marta, Saur Conway, Amy, Varca, Anthony C., Su, Angela, Wu, Lei, Kung, Andrew L., Ferrando, Adolfo A., Bradner, James E., Stegmaier, Kimberly
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2018
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748843/
https://ncbi.nlm.nih.gov/pubmed/29158376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151778
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