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Structures of the CRISPR genome integration complex
CRISPR-Cas systems depend on the Cas1-Cas2 integrase to capture and integrate short foreign DNA fragments into the CRISPR locus, enabling adaptation to new viruses. We present crystal structures of Cas1-Cas2 bound to both donor and target DNA in intermediate and product integration complexes, as wel...
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| Gepubliceerd in: | Science |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5748385/ https://ncbi.nlm.nih.gov/pubmed/28729350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao0679 |
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