A CRISPR-Cas9–integrase complex generates precise DNA fragments for genome integration

CRISPR-Cas9 is an RNA-guided DNA endonuclease involved in bacterial adaptive immunity and widely repurposed for genome editing in human cells, animals and plants. In bacteria, RNA molecules that guide Cas9′s activity derive from foreign DNA fragments that are captured and integrated into the host CR...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Jakhanwal, Shrutee, Cress, Brady F, Maguin, Pascal, Lobba, Marco J, Marraffini, Luciano A, Doudna, Jennifer A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
RNA and RNA-protein complexes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034620/
https://ncbi.nlm.nih.gov/pubmed/33693715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab123
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