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A CRISPR-Cas9–integrase complex generates precise DNA fragments for genome integration
CRISPR-Cas9 is an RNA-guided DNA endonuclease involved in bacterial adaptive immunity and widely repurposed for genome editing in human cells, animals and plants. In bacteria, RNA molecules that guide Cas9′s activity derive from foreign DNA fragments that are captured and integrated into the host CR...
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| Publicado en: | Nucleic Acids Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8034620/ https://ncbi.nlm.nih.gov/pubmed/33693715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab123 |
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