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Mutations in Cas9 enhance the rate of acquisition of viral spacer sequences during the CRISPR-Cas immune response

Clustered regularly interspaced short palindromic repeat (CRISPR) loci and their associated (Cas) proteins encode a prokaryotic immune system that protects against viruses and plasmids. Upon infection, a low fraction of cells acquire short DNA sequences from the invader. These sequences (spacers) ar...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Heler, Robert, Wright, Addison, Vucelja, Marija, Bikard, David, Doudna, Jennifer, Marraffini, Luciano
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5218886/
https://ncbi.nlm.nih.gov/pubmed/28017588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.11.031
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