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Mutations in Cas9 enhance the rate of acquisition of viral spacer sequences during the CRISPR-Cas immune response
Clustered regularly interspaced short palindromic repeat (CRISPR) loci and their associated (Cas) proteins encode a prokaryotic immune system that protects against viruses and plasmids. Upon infection, a low fraction of cells acquire short DNA sequences from the invader. These sequences (spacers) ar...
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| 發表在: | Mol Cell |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5218886/ https://ncbi.nlm.nih.gov/pubmed/28017588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.11.031 |
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