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Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity

The initial stage of CRISPR–Cas immunity involves the acquisition of foreign DNA spacer segments into the host genomic CRISPR locus. The nucleases Cas1 and Cas2 are the only proteins conserved amongst all CRISPR–Cas systems, yet the molecular functions of these proteins during immunity are unknown....

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Bibliografiske detaljer
Main Authors: Nuñez, James K., Kranzusch, Philip J., Noeske, Jonas, Wright, Addison V., Davies, Christopher W., Doudna, Jennifer A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075942/
https://ncbi.nlm.nih.gov/pubmed/24793649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2820
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