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Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity

The initial stage of CRISPR–Cas immunity involves the acquisition of foreign DNA spacer segments into the host genomic CRISPR locus. The nucleases Cas1 and Cas2 are the only proteins conserved amongst all CRISPR–Cas systems, yet the molecular functions of these proteins during immunity are unknown....

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Detalhes bibliográficos
Main Authors: Nuñez, James K., Kranzusch, Philip J., Noeske, Jonas, Wright, Addison V., Davies, Christopher W., Doudna, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075942/
https://ncbi.nlm.nih.gov/pubmed/24793649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2820
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