The initiation, propagation and dynamics of CRISPR-SpyCas9 R-loop complex

CRISPR-Cas9 system has been widely used for efficient genome editing. Although the structures of Cas9 protein in complex with single-guided RNA (sgRNA) and target DNA have been resolved, the molecular details about the formation of Cas9 endonuclease R-loop structure remain elusive. Here we examine t...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Zeng, Yan, Cui, Yang, Zhang, Yong, Zhang, Yanruo, Liang, Meng, Chen, Hui, Lan, Jie, Song, Guangtao, Lou, Jizhong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758904/
https://ncbi.nlm.nih.gov/pubmed/29145633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1117
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