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Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9

Prokaryotic CRISPR-Cas adaptive immune systems utilize sequence specific RNA-guided endonucleases to defend against infection by viruses, bacteriophages and mobile elements, while these foreign genetic elements evolve diverse anti-CRISPR proteins to overcome the CRISPR-Cas-mediated defense of the ho...

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Publicat a:Mol Cell
Autors principals: Yang, Hui, Patel, Dinshaw J.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595222/
https://ncbi.nlm.nih.gov/pubmed/28602637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.05.024
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