Dysfunction of Autophagy and Endosomal-Lysosomal Pathways: Roles in Pathogenesis of Down Syndrome and Alzheimer’s Disease

Individuals with Down syndrome (DS) have an increased risk of early-onset Alzheimer’s Disease (AD), largely owing to a triplication of the APP gene, located on chromosome 21. In DS and AD, defects in endocytosis and lysosomal function appear at the earliest stages of disease development and progress...

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Bibliographic Details
Published in:Free Radic Biol Med
Main Authors: Colacurcio, Daniel J., Pensalfini, Anna, Jiang, Ying, Nixon, Ralph A.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748263/
https://ncbi.nlm.nih.gov/pubmed/28988799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.10.001
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