Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)

Lysosomal failure underlies pathogenesis of numerous congenital neurodegenerative disorders and is an early and progressive feature of Alzheimer's disease (AD) pathogenesis. Here, we report that lysosomal dysfunction in Down ayndrome (trisomy 21), a neurodevelopmental disorder and form of early...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Jiang, Ying, Sato, Yutaka, Im, Eunju, Berg, Martin, Bordi, Matteo, Darji, Sandipkumar, Kumar, Asok, Mohan, Panaiyur S., Bandyopadhyay, Urmi, Diaz, Antonio, Cuervo, Ana Maria, Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607756/
https://ncbi.nlm.nih.gov/pubmed/31043483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0578-19.2019
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