Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)

Lysosomal failure underlies pathogenesis of numerous congenital neurodegenerative disorders and is an early and progressive feature of Alzheimer's disease (AD) pathogenesis. Here, we report that lysosomal dysfunction in Down ayndrome (trisomy 21), a neurodevelopmental disorder and form of early...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Jiang, Ying, Sato, Yutaka, Im, Eunju, Berg, Martin, Bordi, Matteo, Darji, Sandipkumar, Kumar, Asok, Mohan, Panaiyur S., Bandyopadhyay, Urmi, Diaz, Antonio, Cuervo, Ana Maria, Nixon, Ralph A.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607756/
https://ncbi.nlm.nih.gov/pubmed/31043483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0578-19.2019
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