FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome

Calcineurin is an essential Ca(2+)-dependent phosphatase. Increased calcineurin activity is associated with α-synuclein (α-syn) toxicity, a protein implicated in Parkinson’s Disease (PD) and other neurodegenerative diseases. Calcineurin can be inhibited with Tacrolimus through the recruitment and in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Caraveo, Gabriela, Soste, Martin, Cappelleti, Valentina, Fanning, Saranna, van Rossum, Damian B., Whitesell, Luke, Huang, Yanmei, Chung, Chee Yeun, Baru, Valeriya, Zaichick, Sofia, Picotti, Paola, Lindquist, Susan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748183/
https://ncbi.nlm.nih.gov/pubmed/29229832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711926115
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg